Formerly Known as PY Genrone Intermediates Pvt. Ltd.

High Purity. Trusted Bromo Compounds for Advanced Pharmaceutical Synthesis.

Supplying quality chemical building blocks for the pharmaceutical industry.

BROMO COMPOUNDS

2-Cyano-4-Bromo Methyl Biphenyl

Product overview

2-Cyano-4-bromomethyl biphenyl is an important intermediate in pharmaceutical manufacturing, primarily used in the synthesis of SARTAN drugs, which are widely prescribed antihypertensive (blood pressure-lowering) medications. In chemical synthesis pathways, this compound acts as a building block for constructing the biphenyl-tetrazole framework commonly found in angiotensin II receptor blockers (ARBs). These drugs work by blocking the action of angiotensin II, a hormone that narrows blood vessels. By inhibiting this pathway, SARTAN medicines help in:
  • Relaxing blood vessels
  • Improving blood flow
  • Reducing blood pressure
  • Lowering risk of cardiovascular complications such as stroke and heart failure
Because of its role in creating these life-saving drugs, this intermediate is considered highly valuable in bulk API manufacturing and pharmaceutical R&D pipelines.
Parameter Specification Test Method
Product Name 2-Cyano-4-Bromo Methyl Biphenyl In-house
CAS No. 114772-54-2 In-house
Product Code Bromo-OTBN In-house
Purity KSM for all Sartan Group of APIs HPLC
Appearance White to off-white powder Visual
Assay (By HPLC) NLT 98.0% HPLC
Moisture (Karl Fischer) NMT 1.0% KF
Melting Point 105–110°C In-house
Residual Solvents Complies with ICH Q3C GC
Note: The above specifications are typical and may vary as per customer requirements.

Key Safety Information

  • Use appropriate personal protective equipment (PPE) during handling
  • Avoid inhalation of dust or direct skin/eye contact
  • Handle in well-ventilated and controlled manufacturing environments
  • Follow GMP-compliant material handling procedures
  • Refer to Safety Data Sheet (SDS) for detailed handling and emergency guidance
This pharmaceutical intermediate is intended exclusively for industrial pharmaceutical manufacturing and research applications, particularly in the synthesis of SARTAN-class cardiovascular drugs. It is not intended for direct medicinal or human use.

Safety Precaution

  • Handle only within certified pharmaceutical manufacturing facilities
  • Ensure use of appropriate personal protective equipment (PPE) at all times
  • Prevent direct exposure through inhalation, skin contact, or eye contact
  • Maintain proper containment and follow established GMP protocols
  • Dispose of material strictly in accordance with applicable regulatory and environmental guidelines

Frequently Asked Questions (FAQs)

Contract manufacturing is a business model where a pharmaceutical company outsources manufacturing to a specialized partner. In API contract manufacturing, the manufacturer produces pharmaceutical intermediates or APIs according to the customer’s validated process and quality specifications.

A Contract Manufacturing Organization (CMO) manufactures products using a customer-provided process, while a CDMO develops the process and manufactures it. PYG Lifesciences operates as a Contract Manufacturing Organization (CMO) focused on manufacturing execution and commercial supply.

The process begins with documentation review, followed by technical evaluation, pilot validation, quality assessment, and commercial manufacturing approval to ensure a smooth transition into production.

Yes. PYG Lifesciences operates a cGMP-certified manufacturing facility supported by documented quality systems, experienced technical teams, and commercial-scale infrastructure.

Yes. PYG Lifesciences operates an in-house quality control laboratory equipped with HPLC, GC, KF Titrator, UV Cabinet, Analytical Weighing Balance, pH/Conductivity Meter, and other analytical instruments used for batch verification and quality assessment.

PYG supports Friedel-Crafts, Hofmann Reaction, Halogenations, Sandmayer, Suzuki Coupling, Condensation, Oxidation/Reduction, Nitration, and Grignard Reaction across a temperature range of -50°C to 200°C.

Among leading API contract manufacturing companies, PYG Lifesciences offers cGMP-certified infrastructure, experienced technical teams, robust quality systems, and reliable commercial-scale manufacturing for pharmaceutical API intermediates.

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Advanced Bromine-Based Chemical Solutions