INTRODUCTION
Speciality chemicals have become important to the pharmaceutical industry, particularly in the production of pharmaceutical Intermediates.
These chemicals are used at various stages of drug manufacturing—whether as raw materials, pharma Intermediates, or even at the final stages.
Over the years, the demand for these chemicals has grown, with the market projected to grow significantly.
By 2020, their usage was expected to increase by 4 to 5 times, reaching a value of $80 to $100 billion, up from $22 billion.
THE ROLE OF SPECIALITY CHEMICALS IN PHARMACEUTICAL MANUFACTURING
Speciality chemicals serve a variety of functions in the pharmaceutical industry. At the early stages of drug development, these chemicals often act as Intermediates—essential substances that enable the synthesis of active pharmaceutical ingredients (APIs).
Here are a few examples of commonly used speciality chemicals in pharmaceutical production:
- Cyclopropane Carbonyl Chloride
This chemical is a prime intermediate used in pharmaceutical manufacturing. However, it’s highly sensitive and must be stored carefully, away from oxidising agents, metals, and moisture. To ensure safety, it is often kept in an inert gas environment.
- Cyclopropane Carboxylic Acid
A clear liquid, Cyclopropane Carboxylic Acid has a range of applications. It’s not only used as an intermediate in pharmaceuticals but also in electronics and chemicals. Certain derivatives of this acid, like alkynyl esters, even find use as pesticides, showcasing its versatility.
- 2-Dimethylaminoisopropyl Chloride Hydrochloride
Another Intermediate, this compound plays a role in synthesising lipophilic chalcones, which are used as anti-tubercular agents. It’s hygroscopic and soluble in water, making it a sensitive chemical that requires careful handling to avoid reactions with oxidising agents.
SAFETY AND STORAGE: CRITICAL CONSIDERATIONS
The sensitive nature of speciality chemicals means they require careful handling, storage, and transportation. Many speciality chemicals, like Cyclopropane Carbonyl Chloride, need to be stored in controlled environments to prevent hazardous reactions.
Making sure proper storage conditions are important for maintaining the integrity of the chemicals and ensuring safety in the manufacturing process.
THE GROWING MARKET FOR SPECIALTY CHEMICALS
As the pharmaceutical industry continues to grow, the role of speciality chemicals is becoming even more significant. The global market for these chemicals is projected to continue expanding, driven by increased demand for more advanced and effective drugs.
CONCLUSION
From their use in early-stage Intermediates to their impact on final drug formulations, these chemicals play a role in modern medicine.
As pharmaceutical companies continue to innovate, the importance of specialty chemicals will only grow, making them a key driver of the industry’s future.